MACS® GMP Recombinant Human Interleukin 1β
Description Interleukin-1 beta (IL-1β) is a pro-inflammatory cytokine that is secreted mainly by monocytes and macrophages. IL-1β secretion has also been reported for a variety of other cells, including B cells, NK cells, dendritic cells, astrocytes, and microglial cells. It mediates inflammatory responses in B cells, T cells, and NK cells by inducing the production of cytokines, such as IL-2, IL-3, IL-6, as well as interferons. MACS GMP Recombinant Human Interleukin 1β is lyophilized without carrier protein or preservatives. A lot-specific certificate confirms identity, molecular mass, specific activity, sterility, purity, endotoxin content, and host-cell DNA content. Applications MACS GMP Recombinant Human Interleukin 1β can be used for a variety of applications, including the ex vivo generation of human dendritic cells from enriched CD14+ monocyte populations.1-3 MACS GMP Recombinant Human Interleukin 1β is not intended for human in vivo application. Quality Statement MACS GMP Recombinant Human Interleukin 1β may be used for research or ex vivo cell culture processing. MACS GMP Recombinant Human Interleukin 1β is manufactured and tested under a certified ISO 9001 quality system and in compliance with relevant GMP guidelines. It is designed following the recommendations of USP <1043> on ancillary materials. No animal- or human-derived components are used for manufacturing.

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